Of the over 6 billion world population, 2 billion have evidence of HBV infection. The majority has been infected with HBV acutely, and 350 million people are living with Chronic Hepatitis B (CHB) infection currently.  
 
Chronic hepatitis B (CHB) infection affects 350 million people worldwide, including 25 million in the United States, Europe, and Japan. In the United States alone, the diagnosis rate is pegged at 30% and treatment rate at only 10%.  
 
Because of- the high incidence and risk of liver injury, CHB is a major global health and economic burden. Every year, close to a million people die due to CHB infection–related complications including cirrhosis and hepatocellular carcinoma

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